Hello, my dear friends I am here again with the excited and new story. I am going to share some exciting facts on the Researchers Edit To Gene Reducing Blood Cholesterol Levels: Using the cutting-edge CRISPR/Cas9 genetic engineering technique, researchers, including one of Indian-origin, have successfully turned off a gene that regulates cholesterol levels in adult mice.
Researchers Edit To Gene Reducing Blood Cholesterol Levels
The silencing of the gene led to reduced blood cholesterol levels, and gene repression is lasting for six months after a single treatment, said the study published online in the journal Nature Communications. Gene Reducing Blood Cholesterol Levels
The CRISPR/Cas9 system is on an antiviral defense mechanism in bacteria in which the Cas9 enzyme recognizes the viral DNA sequences of previous infections and cuts up invading DNA during re-infection.
Researchers have engineered the CRISPR/Cas9 system to not only locate and cut specific sequences of DNA but to also turning on or off the expression of targeting genes without making permanent changes to the DNA coding sequence. Gene Reducing Blood Cholesterol Levels
Gene Reducing Blood Cholesterol Levels
In the current study, the researchers tested their delivery system by silencing Pcsk9, a gene that is regulating cholesterol levels.Researchers Edit To Gene Reducing Blood Cholesterol Levels.
While several drugs have developed to treat high cholesterol and cardiovascular disease by blocking the activity of Pcsk9, this new approach can prevent Pcsk9 from being made. Gene Reducing Blood Cholesterol Levels
We previously using these same types of tools to turn genes on and off in cultured cells. And we wanted to see if we can also deliver them to animal models with an approach that is relevant for gene therapy. Charles Gersbach, Associate professor at Duke University in North Carolina.
While the experiment was successful, the researchers also observed the release of liver enzymes into the blood.
How to reduce Blood Cholesterol Levels
In the following injection, we see the levels of our target gene, Pcsk9, were reduced. But we also observed increases in expression of many immune cell genes.Researchers Edit To Gene Reducing Blood Cholesterol Levels
That indicates that immune cells were infiltrating the liver after we are delivering. Cas9 to the mice, says Pratiksha Thakore, the Ph.D. student who let the work in Gersbach’s lab. “Gene Reducing Blood Cholesterol Levels”
Gaining a better understanding of this immune response and how to modulating. It will become essential for using Cas9 technologies for therapies, Thakore says.
So, these are the points to describe the Researchers edit to Gene reducing blood cholesterol levels.